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M9460652.TXT
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1994-06-25
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Document 0652
DOCN M9460652
TI Cytotoxic T-lymphocytes that kill autologous CD4+ lymphocytes are
associated with CD4+ lymphocyte depletion in HIV-1 infection.
DT 9408
AU Grant MD; Smail FM; Rosenthal KL; Department of Pathology, McMaster
University, Hamilton, Ontario,; Canada.
SO J Acquir Immune Defic Syndr. 1994 Jun;7(6):571-9. Unique Identifier :
AIDSLINE MED/94231461
AB Human immunodeficiency virus type 1 (HIV-1)-infected individuals, but
not HIV-seronegative controls, have non-HLA-restricted T-cell receptor
alpha beta+ CD8+ cytotoxic T-lymphocytes (CTL) that kill activated
uninfected CD4+ lymphocytes. In vitro stimulation of peripheral blood
mononuclear cells from HIV-1-infected individuals with concanavalin A
(Con A) or by coculture with phytohemagglutinin-activated autologous
lymphoblasts induced CTL that killed autologous and heterologous CD4+
lymphocytes, but not Con A-activated CD8+ lymphocytes or Epstein-Barr
virus (EBV)-transformed B lymphocytes. EBV did not stimulate such CTL in
two subjects tested, although stimulation with Con A or autologous
lymphoblasts induced CTL activity against CD4+ lymphocytes in both
subjects. CTL activity against autologous CD4+ lymphocytes varied over
time; killing of heterologous CD4+ lymphocytes was often higher than
that of autologous CD4+ lymphocytes. HIV-infected individuals with Con
A-inducible CTL against autologous CD4+ lymphocytes lost more CD4+
lymphocytes within 6 months of testing than HIV-infected individuals
with no such CTL (p < .01). The mean (+/- SD) decrease in CD4+
lymphocyte counts in a group of HIV-infected individuals with CTL
activity against autologous CD4+ lymphocytes was 121 +/- 84, or 36%, of
total CD4+ lymphocytes over 6 months. In contrast, there was no
significant change in mean CD4+ lymphocyte count over 6 months in a
group of HIV-infected individuals without CTL activity against
autologous CD4+ lymphocytes. In some HIV-infected individuals, CTL
activity against autologous CD4+ lymphocytes fell coincident with a drop
in CD4+ lymphocyte number in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)
DE Cytotoxicity, Immunologic Follow-Up Studies Herpesvirus 4,
Human/IMMUNOLOGY Human HIV Infections/*IMMUNOLOGY Lymphocyte
Transformation Support, Non-U.S. Gov't T-Lymphocytes,
Cytotoxic/*IMMUNOLOGY T4 Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).